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ČSN EN ISO 16640 This document focuses on monitoring the activity concentrations of radioactive gases. They allow the calculation of the activity releases, in the gaseous effluent discharge from facilities producing positron emitting radionuclides and radiopharmaceuticals. Such facilities produce short-lived radionuclides used for medical purposes or research and can release gases typically including, but not limited to 18F, 11C, 15O and 13N. These facilities include accelerators, radiopharmacies, hospitals and universities. This document provides performance based criteria for the design and use of air monitoring equipment including probes, transport lines, sample monitoring instruments, and gas flow measuring methods. This document also provides information on monitoring program objectives, quality assurance, development of air monitoring control action levels, system optimisation and system performance verification. The goal of achieving an unbiased measurement is accomplished either by direct (in-line) measurement on the exhaust stream or with samples extracted from the exhaust stream (bypass), provided that the radioactive gases are well mixed in the airstream. This document sets forth performance criteria and recommendations to assist in obtaining valid measurements.